Midfielder Ozil, a club record £42.4m signing in the summer, has shaken off an illness while striker Giroud has recovered from a knee problem.
Defender Per Mertesacker is available after missing the win at Sunderland.
Arsenal's growing injury list
Santi Cazorla - ankle
Yaya Sanogo - back
Tomas Rosicky - hamstring
Lukas Podolski - hamstring
Alex Oxlade-Chamberlain - knee
Mikel Arteta - thigh
Abou Diaby - knee
Defensive player Isaac Hayden and and forward Chuba Akpom are both in Arsene Wenger's 18-man squad.
The Gunners have a long lost of injuries to key midfield and attacking players, with Lukas Podolski, Alex Oxlade-Chamberlain, Abou Diaby, Santi Cazorla and Mikel Arteta all sidelined.
Giroud has recovered from the knock to his knee he picked up during the win at the Stadium of Light last weekend. The 26-year-old said he was looking forward to playing against a club he is familiar with.
"I know Marseille very well, it is a big atmosphere there and an amazing crowd," The France international, who signed from Montpellier in 2012, told the Arsenal website.
"I am sure we will fight as we need a first win in the Champions League to start well. We need to be strong. Even though we have a lot of injuries, we have a lot of quality and we need to win this game."
Marseille are set to include forward trio Mathieu Valbuena, Andre-Pierre Gignac and Dimitri Payet in their squad, while summer signing, attacking midfielder Florian Thauvin, could make his home debut.
"He has trained a lot and run a lot but he has hardly played any games," Marseille manager Elie Baup said.
"I know he is not yet ready but he needs to reacclimatise to playing competitive games."
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